These are chat archives for openworm/ChannelWorm

5th
Jun 2015
Vahid Ghayoomie
@VahidGh
Jun 05 2015 09:16
@slarson, could generate a better result using 600 GA evaluation + minimization function by Scipy curve_fit
data_vs_candidate_vs_fitted_IV.png
Vahid Ghayoomie
@VahidGh
Jun 05 2015 09:27
One problem with this kind of fitting is the dependency to the I/V curve generated by the author.
For example, here we have activation/inactivation and Ca-dependent inactivation (and their parameters) in the experiment, so I'm using them during I- or V- clamp simulation, but when going to fit it with the I/V plot, I should only consider the activation expression and related parameters. So in the final fitting process, only activation parameters would be optimized, and the other ones remaining intact.
Vahid Ghayoomie
@VahidGh
Jun 05 2015 09:34
*Actually activation parameters, g and reverse potential