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You'll need to provide more information for us to be able to properly diagnose and suggest a solution to the problem. What specific behavior are you experiencing when attempting to launch Spyder? What exact error messages? How are you launching it (Shortcut, Navigator, Anaconda prompt?) What version of Anaconda, Python and Spyder are you using? What versions of Qt/PyQt?
Try the other methods of starting Spyder, particularly launching it from the Anaconda prompt (
spyder) and pasting the exact error message from the console. Also, try upgrading (
conda update pyqt qt spyder spyder-kernels qtconsole qtpy ipykernel jupyter_client ipython) relevant packages, and if that doesn't work, try downgrading Qt (
conda install pyqt=5.6). Finally, please try the steps listed in the Spyder Troubleshooting Guide, specifically the Basic First Aid and Emergency CPR sections, which resolve the great majority of Spyder installation issues.